Search results for "hereditary nonpolyposis colon cancer"

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Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome : A retrospective analysis from the Finnish National Lynch Syndrom…

2023

IntroductionPatients with Lynch syndrome (LS) have an increased lifetime risk of pancreatic cancer (PC) and biliary tract cancer (BTC). These cancers have a notoriously pessimistic prognosis due to late diagnosis and limited therapeutic options. There are limited data based on small cohorts reviewing PC and BTC in LS patients.MethodsIn this retrospective study of the Lynch Syndrome Registry of Finland (LSRFi), records of genetically verified LS patients diagnosed with PC or BTC between 1982 and 2020 were analyzed.ResultsThirty-nine patients were included: tumor(s) were in the pancreas in 26 patients, in the biliary tract in 10, and in the ampulla of Vater in three. A pathogenic germline var…

Lynch syndrome (LS)Cancer Researchhereditary nonpolyposis colon cancermicrosatellite instability (MSI)3122 Cancerspancreatic cancerPancreatic cancer3121 Internal medicinemikrosatelliititLynch syndromeOncologyhereditary nonpolyposis colon cancer (HNPCC)biliary tract cancerBiliary tract cancermicrosatellite instabilityLynchin oireyhtymähaimasyöpäpaksusuolisyöpä

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PEPhysical Sciences and Engineering
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